Publications

Non-coding single-nucleotide and structural variants affecting the EYS putative promoter cause autosomal recessive retinitis pigmentosa.
Hayman T, Ovadia S, Krishnan J, Bouckaert M, Panneman DM, English M, Valensi J, Cremers FPM, Ben Yosef T, van den Born LI, de Bruijn SE, Roosing S, Banin E, Khateb S, Ashery-Padan R, Coppieters F, Swaroop A, Sharon D.Genet Med. 2025 Jul;27(7):101427. doi: 10.1016/j.gim.2025.101427. Epub 2025 Apr 4.PMID: 40191993

Guidelines to Analyze ChIP-Seq Data: Journey Through QC and Analysis Considerations.
De Kumar B, Krishnan J.Methods Mol Biol. 2025;2889:193-206. doi: 10.1007/978-1-0716-4322-8_14.PMID: 39745614

Establishment, Long-Term Maintenance, and Characterization of Primary Liver Cells from Astyanax mexicanus.
Rajendran N, Deng F, Wang Y, Kenzior O, Krishnan J, Biswas T, Parmely T, Rohner N, Zhao C.Curr Protoc. 2023 Apr;3(4):e736. doi: 10.1002/cpz1.736.PMID: 37068186

Circadian rhythm disruption linked to skeletal muscle dysfunction in the Mexican Cavefish.
Olsen L, Krishnan J, Banks C, Hassan H, Rohner N.Curr Biol. 2023 Apr 10;33(7):R255-R256. doi: 10.1016/j.cub.2023.02.036.PMID: 37040703 Free PMC article.

Circadian rhythm disruption is associated with skeletal muscle dysfunction within the blind Mexican Cavefish.
Olsen L, Krishnan J, Banks C, Hassan H, Rohner N.bioRxiv [Preprint]. 2023 Jan 25:2023.01.25.525368. doi: 10.1101/2023.01.25.525368.Update in: Curr Biol. 2023 Apr 10;33(7):R255-R256. doi: 10.1016/j.cub.2023.02.036.PMID: 36747688 Free PMC article. Preprint.

Poor eyesight reveals a new vision gene.
Biswas T, Krishnan J, Rohner N.Elife. 2022 Aug 5;11:e81520. doi: 10.7554/eLife.81520.PMID: 35929336 Free PMC article.

Liver-derived cell lines from cavefish Astyanax mexicanus as an in vitro model for studying metabolic adaptation.
Krishnan J, Wang Y, Kenzior O, Hassan H, Olsen L, Tsuchiya D, Kenzior A, Peuß R, Xiong S, Wang Y, Zhao C, Rohner N.Sci Rep. 2022 Jun 16;12(1):10115. doi: 10.1038/s41598-022-14507-0.PMID: 35710938 Free PMC article.

The metabolome of Mexican cavefish shows a convergent signature highlighting sugar, antioxidant, and Ageing-Related metabolites.
Medley JK, Persons J, Biswas T, Olsen L, Peuß R, Krishnan J, Xiong S, Rohner N.Elife. 2022 Jun 15;11:e74539. doi: 10.7554/eLife.74539.PMID: 35703366 Free PMC article.

Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish.
Krishnan J, Seidel CW, Zhang N, Singh NP, VanCampen J, Peuß R, Xiong S, Kenzior A, Li H, Conaway JW, Rohner N.Nat Genet. 2022 May;54(5):684-693. doi: 10.1038/s41588-022-01049-4. Epub 2022 May 12.PMID: 35551306 Free PMC article.

Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity.
Xiong S, Wang W, Kenzior A, Olsen L, Krishnan J, Persons J, Medley K, Peuß R, Wang Y, Chen S, Zhang N, Thomas N, Miles JM, Alvarado AS, Rohner N.Curr Biol. 2022 May 23;32(10):2272-2280.e6. doi: 10.1016/j.cub.2022.03.038. Epub 2022 Apr 6.PMID: 35390280 Free PMC article.

Adaptation to low parasite abundance affects immune investment and immunopathological responses of cavefish.
Peuß R, Box AC, Chen S, Wang Y, Tsuchiya D, Persons JL, Kenzior A, Maldonado E, Krishnan J, Scharsack JP, Slaughter BD, Rohner N.Nat Ecol Evol. 2020 Oct;4(10):1416-1430. doi: 10.1038/s41559-020-1234-2. Epub 2020 Jul 20.PMID: 32690906 Free PMC article.

Comparative transcriptome analysis of wild and lab populations of Astyanax mexicanus uncovers differential effects of environment and morphotype on gene expression.
Krishnan J, Persons JL, Peuß R, Hassan H, Kenzior A, Xiong S, Olsen L, Maldonado E, Kowalko JE, Rohner N.J Exp Zool B Mol Dev Evol. 2020 Nov;334(7-8):530-539. doi: 10.1002/jez.b.22933. Epub 2020 Feb 4.PMID: 32017448

Gamete Collection and In Vitro Fertilization of Astyanax mexicanus.
Peuß R, Zakibe Z, Krishnan J, Merryman MS, Baumann DP, Rohner N.J Vis Exp. 2019 May 25;(147). doi: 10.3791/59334.PMID: 31180353

Stable transgenesis in Astyanax mexicanus using the Tol2 transposase system.
Stahl BA, Peuß R, McDole B, Kenzior A, Jaggard JB, Gaudenz K, Krishnan J, McGaugh SE, Duboue ER, Keene AC, Rohner N.Dev Dyn. 2019 Aug;248(8):679-687. doi: 10.1002/dvdy.32. Epub 2019 Apr 15.PMID: 30938001 Free PMC article.

Sweet fish: Fish models for the study of hyperglycemia and diabetes.
Krishnan J, Rohner N.J Diabetes. 2019 Mar;11(3):193-203. doi: 10.1111/1753-0407.12860. Epub 2018 Nov 15.PMID: 30264455 Review.

Early adipogenesis contributes to excess fat accumulation in cave populations of Astyanax mexicanus.
Xiong S, Krishnan J, Peuß R, Rohner N.Dev Biol. 2018 Sep 15;441(2):297-304. doi: 10.1016/j.ydbio.2018.06.003. Epub 2018 Jun 5.PMID: 29883659 

Simple sequence repeats showing ‘length preference’ have regulatory functions in humans.
Krishnan J, Athar F, Rani TS, Mishra RK.Gene. 2017 Sep 10;628:156-161. doi: 10.1016/j.gene.2017.07.022. Epub 2017 Jul 13.PMID: 28712775 

Cavefish and the basis for eye loss.
Krishnan J, Rohner N.Philos Trans R Soc Lond B Biol Sci. 2017 Feb 5;372(1713):20150487. doi: 10.1098/rstb.2015.0487.PMID: 27994128 Free PMC article. Review.

Emerging trends of long non-coding RNAs in gene activation.
Krishnan J, Mishra RK.FEBS J. 2014 Jan;281(1):34-45. doi: 10.1111/febs.12578. Epub 2013 Nov 13.PMID: 24165279  Review.

GATA simple sequence repeats function as enhancer blocker boundaries.
Kumar RP, Krishnan J, Pratap Singh N, Singh L, Mishra RK.Nat Commun. 2013;4:1844. doi: 10.1038/ncomms2872.PMID: 23673629